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As such the overall impact of the manuscript would benefit greatly by detailed editing and potential re-organization. Response: As per your suggestion, we have replaced the section on requirements and detection of dimers with a reference to the original IUPHAR publication

Copper peptides generally need several months before visible hair-density changes can be evaluated

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Managing the Transition: Medical Supervision and Lifestyle Strategies If discontinuation is unavoidable, medical supervision during the transition reduces symptom severity and supports metabolic adjustment

Leone et al., 2019