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The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

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Thyroid dysfunction can amplify HA-CD44 signaling and collagen crosslinking, as evidenced by studies showing that hyaluronic acid promotes COX-2 expression in orbital fibroblasts from patients with thyroid-associated ophthalmopathy via CD44-mediated MAPK and NF-B signaling (187)