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Additionally, their rate constants are many orders of magnitude higher in aqueous solutions [2] than in organic solutions, due to even higher energy barriers

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J Mammary Gland Biol Neoplasia (1997) 2(3):24352

Manhas A, Lone MY, Jha PC (2019) Multicomplex-based pharmacophore modeling in conjunction with multi-target docking and molecular dynamics simulations for the identification of Pf DHFR inhibitors