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Similarly, elevated global DNA methylation, Dnmt activity, and 5-methylcytosine but decreased Tet activity and 5-hydroxymethylcytosine were observed in the GSH-deficient hepatocytes and the liver of HFD-fed mice

The gut-microbiome-metabolism axis seems bidirectional, with GLP-1-producing L-cells reacting to microbial metabolites, especially butyrate and propionate

Feeling full sooner, eating smaller portions, or thinking less about food are common early experiences

Notably, most patients discontinuing treatment after 6 months are those whose initial robust weight loss has transitioned into a maintenance phase, where further reduction is no longer achieved [2, 9]

The detectable effect size is slightly smaller in men than in women

When used alone, the risk is low