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MOTS-c, discovered by researchers at the University of Southern California around 2012, improves glucose metabolism in skeletal muscle, suggesting benefits for diabetes, obesity, and aging

10.1038/sj.jcbfm.9600287 J

Long-term human safety data does not exist, which is the main caution

Body weight was measured every five days for the 60-day duration, while the mice were undergoing behaviour tests

This work may also bring new insights into diseases that alter body composition, such as obesity, type 2 diabetes, adult GHD, acromegaly and glucocorticoid excess

Ipamorelin is a pentapeptide studied in laboratory environments for its selective interaction with growth hormone secretagogue receptor (GHSR) pathways