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To target E2 to -cells without the undesirable effects of general estrogen therapy, we created fusion peptides combining active or inactive glucagon-like peptide-1 (GLP-1) and E2 in a single molecule (aGLP1-E2 and iGLP1-E2 respectively)

Evening dosing (30 to 60 minutes before sleep) is strongly recommended so that nausea and flushing peak during sleep rather than during the day

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IL8 and tumor necrosis factor (TNF), markers of oxidative stress and inflammation, are also increasing (47)

Although it is still not known exactly what causes a person to develop allergies, it is strongly suggested that genetics and environmental exposures play significant roles (per Johns Hopkins Medicine)