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[149] For patients with difficulty falling asleep, melatonin is typically administered 30 minutes to 3 hours before desired bedtime

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These may include: Nausea Constipation Diarrhea Abdominal pain Mild fatigue Injection site sensitivity Gastrointestinal discomfort from slowed gastric emptying In rare cases, more serious side effects like pancreatitis or low blood sugar may occur, especially if you have a history of diabetes mellitus, take sulfonylureas, or are sensitive to incretin-based therapies