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5E, F and Supplementary Fig

Results Search Results A total of 17 studies were identified by literature search [one with two eligible contrasts ( Pooled Effect-Size Between-studies heterogeneity was not significant for VR ( I 2 = 12.8%, Cochran's Q = 24.14, p = 0.19) and CVR ( I 2 = 0%, Cochran's Q = 14.33, p = 0.76) estimates, but as expected, for SMDH there was a significant between-studies heterogeneity ( I 2 = 47.4%, Cochran's Q = 37.15, p = 0.008)

As the key enzyme metabolizing APAP into NAPQI, cytochrome P450 enzymes are also considered to be intriguing target for the treatment of APAP-induced liver injury

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In the Phase III 4WHIM trial, Xolremdi showed a 60% reduction in annualized infection rate compared to placebo

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