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Tirzepatide Tirzepatide is a newer medication that works as a dual GIP/GLP-1 receptor agonist, targeting two hormones involved in appetite and blood sugar regulation

This reversal can lead to inhibitory effects on neuronal activity through mechanisms involving the Na/Ca 2 exchanger (NCX), as well as GABA and glycine transporters 99,102

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Meanwhile, GLP-1 medications, once niche, have gained widespread attention for weight management and metabolic health

Additionally, 4-Octyl itaconate (4OI) suppresses endothelial ferroptosis by activating the Kelch-like ECH-associated protein 1 (Keap1)/Nrf2/GPX4 signaling pathway [89]

But here's the million-dollar question: which one should you choose