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They work by engaging the same receptors on target cells as glucagon does, triggering a cascade of different effects in our body including blood sugar regulation, insulin secretion and appetite control and potentially even immune modulation
Thus, we speculate that T3 can increase the production of non-12-OH FXR-antagonistic BAs in human likely attributed to the same mechanisms in mice, thereby promoting GLP-1 and insulin production by suppressing intestinal FXR signaling
Supporting your bodys natural GLP-1 production isnt about forcing appetite down
No, you should not take liraglutide and semaglutide together
In humans, GLP1 meds were shown to reduce activity in anticipation areas of the brain (like the insula) and increase activity when actually eating , helping curb cravings