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Cell transfection Cells were transfected with pcDNA 3.1 overexpression vectors (pcDNA 3.1-YTHDF1 and pcDNA 3.1-SLC7A5, with the empty pcDNA 3.1 vector as a negative control) and siRNAs (Invitrogen) targeting YTHDF1 and SLC7A5 (si-YTHDF1, si-SLC7A5, with non-targeting siRNA (si-NC) as a negative control)

In mouse models of diseases such as ALI, liver fibrosis, NAFLD, and NASH, treatment with lipophilic antioxidants was shown to prevent disease progression and extend life expectancy

It helps detoxify the liver, regenerate liver cells, and improve liver function

Sharma AK, Khandelwal R, Wolfrum C

Digestion of hesperidin by intestinal bacteria produces a compound called hesperetin, along with other metabolites