CMS has completed two negotiation cycles so far: the first set of 10 drugs took effect in 2026, and a second set of 15 drugs, including Ozempic and Wegovy, takes effect in 2027.
The pivotal programs are public, the STEP trials for semaglutide in weight management ( The New England Journal of Medicine , 2021), SURMOUNT for tirzepatide in weight management (NEJM, 2022), and SURMOUNT-OSA for tirzepatide in obstructive sleep apnea (NEJM, 2024)
Ten seconds of holding the needle in place after injection completion
GLPatch is in the supplement lane - not the pharmaceutical lane
Adverse events caused treatment discontinuation in 4.3%, 7.1%, 6.2%, and 2.6% of participants receiving 5-mg, 10-mg, 15-mg tirzepatide doses and placebo, respectively [49]
In addition to food intake, vagal afferents also mediate the ability of intestinal nutrients to regulate hepatic glucose production