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Lifestyle factors such as maternal smoking, alcohol consumption, and recreational drug use stimulate production of unfavorable amounts of ROS leading to OS, which renders physiological processes of female reproduction and the fetus vulnerable to oxidant-induced damage

Warn patients not to drive or operate dangerous machinery unless they are tolerant to the effects of hydrocodone bitartrate and acetaminophen tablets and know how they will react to the medication (see PRECAUTIONS, Information for Patients)