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The evidence for divided dosing over single daily dosing is not established in humans

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doi: 10.1038/nature14154 56 Onengut-GumuscuSChenWMBurrenOCooperNJQuinlanARMychaleckyjJCet al

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Real-world effectiveness of homologous and heterologous BNT162b2, CoronaVac, and AZD1222 booster vaccination against Delta and Omicron SARS-CoV-2 infection

There was one death in each of the certolizumab pegol treatment arms, one due to a myocardial infarction, and one due to sudden death of unknown cause