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Porro D, Bianchi MM, Brambilla L, Menghini R, Bolzani D, Carrera V, Lievense J, Liu CL, Ranzi BM, Frontali L, Alberghina L

[1] [2] [12] The best supporting evidence is indirect: in STEP 4 and SURMOUNT-4, people who stopped these medications regained most of their lost weight, while people who continued kept their results

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Previous to the beginning of the protocol, all participants signed an informed consent

This study innovatively focuses on the mechanism by which FOXO4-DRI induces apoptosis in senescent endothelial cells, demonstrating that it functions by activating the p53/BCL-2/Caspase-3 signaling pathway to promote selective apoptosis of these cells