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However, in an editorial in Molecular Psychiatry, Substantial evidence has been accumulated that reveals metabolic defects in both the peripheral and central tissue of patients with SZ (see reviews by 31 P MRS) phospholipids and polyunsaturated fatty acids (PUFAs) were shown in SZ patients ( Moreover, there are several paradigmatic conditions such as Down syndrome, phenylketonuria, and various lipidoses ( CONCLUSION AND PERSPECTIVES During the purine catabolism, there are three major purine bases and their corresponding ribonucleosides, which consist of adenine/adenosine, G/Gr, and Hx/inosine ( Figure 2 )

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Eur J Pharmacol 991: 177305

149 MangraviteL

FIGURE 1 3.2 FOXO4-DRI effectively improves vascular function in prematurely aging mice To further explore the role of FOXO4-DRI in aged mice, we constructed prematurely aging mouse model by administering D-galactose (200 mg/kg) intraperitoneally for 8 weeks