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The activation of other pro-survival signaling pathways, such as the PI3K/Akt, MAPK, and NF-kB pathways, as well as the regulation of DNA repair mechanisms (e.g., ATM/ATR and Chk1/Chk2 pathways), also play critical roles in paclitaxel resistance

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in addition, chronic accumulation of such metals is known to increase the risk for neurodegenerative disorders, particularly of AD and PD

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