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Exercise-Induced Oxidative Stress Intense or prolonged exercise generates substantial oxidative stress through increased oxygen consumption and metabolic rate, increased mitochondrial electron leakage producing reactive oxygen species, recruitment of inflammatory immune cells to exercising muscles, and mechanical stress on tissues producing oxidative damage

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GH stimulation may theoretically encourage tumor growth, so this therapy is avoided in anyone with an active malignancy or a history of cancer that is not in complete remission

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