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Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions

GM also regulates BA synthesis

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Hair biology is the second major area of research interest, and it's more mechanistically indirect than the skin data

10.1016/S0891-5849(99)00051-9 291 WiniewskiM.BieniekA.RoszekK.CzarneckaJ.BolibokP.FerrerP.et al (2018)