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Pickart's foundational work and subsequent studies on copper peptides and wound closure point to upregulation of matrix metalloproteinases, the enzymes responsible for remodeling collagen into organized structure during repair, rather than the disorganized collagen deposition that produces visible scarring

Stability can be affected by formulation, storage, heat and oxidation

Individual response varies

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Works through completely different mechanisms, adding a regenerative effect that complements standard treatments