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In the trials not every participant advanced to the full 2.4 mg of each component, and dose flexibility was built into the design the target is reached gradually and not universally, so this is reference data describing the trial schedule, not a fixed prescription

The timeline depends on your individual magnesium status, the severity of symptoms, and the type of magnesium used

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Murphy, E

Nevertheless, his case is sometimes cited as an example of vitamin B12 deficiency and how severe it can get with time, if left untreated, it can lead to serious health issues, including neurological symptoms like dementia

Med Pregl