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Some practitioners explore combining human chorionic gonadotropin (HCG) with tirzepatidea dual GIP and GLP-1 receptor agonistto address metabolic resistance through multiple mechanisms

doi: 10.1021/bi00164a017

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426HuartAKleinJGonzalezJBuffin-MeyerBNeauEDelageCCaliseDRibesDSchanstraJPBascandsJL

Thats the difference between biological plausibility and clinical validation

More recent work by Jerry Turner and others [29, 41] has provided substantial data supporting the presence of two distinct paracellular pathways: the pore pathways that transports ions and small uncharged molecules, and the leak pathway that transports larger molecules regardless of charge