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Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India. Frontiers in Endocrinology vol

The FDAs stated concerns are: (1) theoretical risk of allergic reactions with repeated peptide administration, (2) quality control concerns about compounding purity and consistency, and (3) no Phase 1-3 trials conducted under FDA oversight

And because supplements are basically unregulated in the US, its hard to know what exactly is in Lemmes $72-a-month product

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10.1111/j.1523-1755.2004.09223.x 172

More recent studies continue to confirm its effectiveness, with 2019 research in Obesity showing an average weight loss of 7.5% of body weight over 12 weeks