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When misfolded proteins accumulate in the ER, the UPR is activated to restore homeostasis
doi: 10.1016/0006-2952(94)90272-0
References Ragusa F, Fallahi P, Elia G, et al
Are there side effects of GLP-1 receptor agonists
An open-label uncontrolled trial including 27 patients with T2D and NAFLD treated with liraglutide 0.9 mg/day for 24 weeks showed a trend toward increases in liver-to-spleen attenuation ratio assessed by CT scan and, more importantly, a significant improvement in histological inflammatory scores in 10 subjects undergoing liver biopsies after a prolonged treatment of 96 weeks (64)
In some cases, certain illnesses can be associated with elevated B12, which is why clinicians sometimes investigate further
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