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Understanding the relationship between this medication and leg discomfort requires examining clinical trial data, known side effect profiles, and factors associated with weight loss therapy

Vitamin E reduces ALT and improves histologic features of inflammation, and some Societies recommend it for non-diabetic adults with NASH in the general population, but there is concern from meta-analyses that long-term use may modestly increase all-cause mortality (22, 24)

JAMA 282(18): 173744

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