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The secretion of pro-inflammatory cytokines follows circadian rhythms (109)

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High doses may lead to the K-hole phenomenon, characterized by extreme dissociation without loss of consciousness (Malhotra et al., 1996)

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Pharmacokinetic parameters were calculated descriptively for each participant using noncompartmental methods, with area under the curve (AUC) derived by the trapezoidal rule

Notably, mutations mainly in pfcrt [59] and pfmdr1 [60] differentially influence quinoline drug action and resistance