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In clinical trials, in addition to significantly greater weight loss than placebo, each of these medications showed significant improvements in lipids, glycemic control, hypertension, and waist circumference

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The comparative effectiveness of an expanded 2-year on-treatment analysis that followed patients who stay on the exposure or comparator therapies for a prolonged time showed concordant results with the 1-year on-treatment analysis (Supplementary Table 25)

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Tissue Inhibitor of Metalloproteinase (TIMP) Interactions The balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), determines net proteolytic activity in tissues