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Similar results were found in a clinical study in patients with T2DM, where administration of liraglutide, but not metformin, increased the relative abundance of Akkermansia , which is often associated with the improvement of gastric mucosa and also becomes severely depleted in diabetic patients [115]

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TRIUMPH-4: Knee Osteoarthritis The Most Overlooked Trial TRIUMPH-4 is the retatrutide trial that most guides overlook but for patients with obesity-related joint pain, it may be the most clinically relevant

Research Context Retatrutide was initially developed as a therapeutic candidate for type 2 diabetes and obesity due to its ability to modulate multiple gastrointestinal and endocrine pathways