Risk of bias using Cochrane risk-of-bias tool for randomized trials-Kosibord, 2023
Medication management - from dosage, to refilling prescriptions, to tracking weight loss and mitigating any potential side-effects, with minimum of a monthly telehealth appointment with their clinician
Fat-selective weight loss would be an additional advantage, as the STEP-1 (NCT03548935) trial demonstrated that once-weekly semaglutide 2.4 mg resulted in 3.4 kg (7.5 lb) more loss in lean body mass compared to placebo
This context of high prevalence, progressive natural history, and multisystemic impact underscores the urgent need for effective, broadly applicable pharmacotherapies
This revealed an interaction between the metabolite and mitochondrial trifunctional protein- (MTP), which is known to regulate fatty acid oxidation (FAO) (23)
Weight management involves multiple systems working together, and natural approaches may influence these systems through diverse mechanisms rather than one dominant pathway
