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Understanding Retatrutide: Mechanism and Pharmacology What it is: Retatrutide (LY3437943) is an injectable that activates three metabolic receptors: GLP-1, GIP, and glucagon

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In terms of efficacy, the Wegovy pill led to 13.6% weight loss in a 64-week Phase 3 trial, slightly more than the 11.2% weight loss that orforglipron showed in its 72-week study

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