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Any observed increases in GLP-1 secretion would represent an indirect effect of nutrient sensing rather than direct receptor activation

A previous 20-week, randomized, placebo-controlled, double-blind trial of semaglutide 2.4 mg involving individuals with obesity also found significant reductions in food cravings, as measured by the Control of Eating Questionnaire, versus placebo [8]

Semaglutide works through several key mechanisms: 1

doi: 10.1902/jop.2016.150266 85 RydenLBuhlinKEkstrandEde FaireUGustafssonAHolmerJet al

Johnston, C S, C G Meyer, et J C Srilakshmi

Gastrointestinal Sensitivity and Individual Tolerability Variation Why do some patients tolerate one formulation better than another