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All quantitative safety findings derive from animal and in-vitro models

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It helps orchestrate healing at the cellular level, particularly after injury

Sumner JB, Dounce AI (1937)

The most common phase II drug-metabolizing enzymes are UDP-glucuronosyltransferases (UGTs), sulfotransferases (SULTs), N-acetyltransferases (NATs), glutathione S-transferases (GSTs), methyltransferases (thiopurine S-methyltransferases (TPMTs), catechol O-methyltransferases (COMTs)) and acyltransferases (Jancova et al., 2010

Barragan JM, Rodriguez RE, Blazquez E: Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(736) amide in rats