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Metabolic Effects: These medications may influence blood sugar regulation and appetite signaling in some patients

7.2 Proteasome inhibitors In MM cells, high proteasome activity is a crucial factor for degrading misfolded immunoglobulins to ensure cell survival

Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV et al

doi:10.1007/s00592-025-02525 71

The first recombinant IGF-1 drugs have recently received US Food and Drug Administration (FDA) approval for the treatment of IGF-1 deficiency, and intense efforts for the expansion of its use in diseases such as sarcopenia, muscular dystrophy and amyotrophic lateral sclerosis are ongoing [6567]

The relationship between GLP-1 therapy and depression remains an active area of clinical investigation, with recent data suggesting the risk may vary based on individual biology and baseline mental health status