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Gliotoxin Biosynthesis De novo gliotoxin biosynthesis occurs as follows: Phenylalanine and serine are condensed by the non-ribosomal peptide synthetase GliP (Chang et al., 2013) to form intermediate (1) (Figure 3)
This epigenetic mechanism is consistent with the broader Khavinson framework for bioregulator peptides, which proposes that short peptide sequences (27 amino acids) can penetrate nuclear membranes and interact directly with DNA or chromatin-associated proteins to modulate tissue-specific gene expression
A 600mg IV dose outperforms a 2,000mg oral capsule every time
A., Chandra, M
Zhang G, Wu S, Xia G
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