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Wang D, Li Z, Messing EM, Wu G (2002)

doi: 10.1091/mbc.e08-01-0080 83 ItakuraEMizushimaN

In conclusion, the liver selectivity of resmetirom is achieved through two complementary design principles: (i) a 28-fold higher binding affinity for THR- compared to THR- [18], and (ii) preferential first-pass hepatic extraction that results in a favorable liver-to-plasma exposure ratio