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Lumbar spine BMD tended to decrease in the LC group after the 3-month intervention (p = 0.069), but no other changes in BMD were noted (Table 3)

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Schwechheimer et al., 2016)

Given the limited regenerative capacity of neurons, sustained disruption of proteostasis progressively overwhelms cellular quality control systems, leading to synaptic dysfunction, neurodegeneration and irreversible cognitive or motor decline