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The discovery that gut microbial metabolism of L -carnitine involves a second quantitatively significant sequential pathway for TMA formation from distinct microbial taxa suggests numerous targets are at hand if one wishes to pharmacologically manipulate the catabolism of carnitine into TMA/TMAO for potential treatment or prevention of CVD, such as through shifting of gut bacterial composition (probiotic, prebiotic) or inhibition of bacterial enzymatic activities
Synthesis 54 , 35583567 (2022)
NADPH solution was added to the plates, and the absorbance was measured at 412 nm using a CLARIOstar microplate reader (CLARIOstar, BMG LABTECH, Germany)
[3] Frias JP, et al
Burns Trauma 6 , 123 (2018)
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