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The largest evidence to date comes from the Adjust-T1D trial, presented at this years American Diabetes Association Scientific Sessions

In iron deficiency, nuclear receptor coactivator 4 (NCOA4) specifically binds iron-rich ferritin to autophagosomes through FTH1 and transports it to the lysosome for iron release, while NCOA4 can be degraded through ubiquitination, which affects that stability of ferritin

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Vasireddi N, Hahamyan H, Salata MJ, et al

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