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Synthesis and pharmacological characterization of 2-(2,6-dichlorophenyl)-1-((1 s,3r)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1 -methyl-3,4-dihydroisoquinolin-2(1 h)-yl)ethan-1-one (ly3154207), a potent, subtype selective, and orally available positive allosteric modulator of the human dopamine D1 receptor

The AA and internal standard (hydroquinone) were resolved using a reverse-phase C18 Atlantis (5 m, 4.6 mm 150 mm, Waters Corporation) chromatography column and detected with a UV/Vis detection system (SPD-20A) at 257 nm and 293 nm

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