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Mitochondrial malfunction triggers ROS overproduction and an influx of Ca 2+ , resulting in vacuole formation, MAPK activation, and the initiation of paraptosis in prostate cancer cells [151]

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These medications may benefit patients with metabolic liver disease regardless of diabetes status, especially if metabolic risk factors are present

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In certain instances, these targeted therapies modulate autophagy-related pathways as a component of the treatment regimen for NSCLC (245248)