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Regarding berberines lipid-lowering effect, there is evidence that berberine shunts the body's lipid production through the AMP-activated protein kinase

While reducing body mass index (BMI) does reduce the risk of cancer incidence, it is not to the extent that lowering BMI reduces mortality risk

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[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Patti M.E., Butte A.J., Crunkhorn S., Cusi K., Berria R., Kashyap S., Miyazaki Y., Kohane I., Costello M., Saccone R., et al

So keep in mind there's no one supplement, no one diet, no one surgery, no one medication that is going to completely treat endometriosis because endometriosis is affecting the immune system, the gut [00:23:00] blood sugar regulation, uh, pain signaling and hormones and, um, your nervous system like and all at the same time