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Moreover, the peptide was shown to lower the melting temperature of DNA by 41C in vitro

There have also been anecdotal reports of insomnia as a side effect, although the drugs manufacturer, Novo Nordisk, does not list it as a known adverse effect

The main findings in this study were that tirzepatide demonstrated greater mean weight loss than semaglutide but with a greater rate of AEs, primarily GI AEs