Tirzepatide is a dual-agonist , meaning it works by targeting two hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Retatrutide is a triple-agonist , meaning it targets three hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Glucagon: affects energy use and fat metabolism Early studies show that retatrutide may be more successful than tirzepatide at managing diabetic kidney disease, as well as for weight control, while tirzepatide may be better at managing blood glucose
"Kiwis contain a natural enzyme called actinidin, which aids digestion, which can make them particularly beneficial for GLP-1 users experiencing gastrointestinal side effects." Lauren Manaker, M.S., RDN Adding these fruits to your diet isnt just about flavor its about getting the nutrients your body needs to make the most of your GLP-1 therapy
PF-06372222 and key residues are shown as sticks
This is particularly useful for high-protein meals where incomplete digestion of sulfur-containing amino acids is a major contributor to hydrogen sulfide production
SGLT2 inhibitors, but not GLP-1 receptor agonists, reduce incidence of gout in people living with type 2 diabetes across the therapeutic spectrum
semaglutide Semaglutide Drug Names : Ozempic (for T2DM) - injectable Wegovy (for weight management) - injectable Rybelsus (oral) - 1st oral GLP-1 agonist (FDA approved 9/20/19) Drug Category : GLP-1 receptor agonist, hypoglycemic Synthetic peptide analog of GLP-1 Mechanism of Action: Synthetic peptide that is chemically identical to GLP-1, except for three amino acid substitutions and modifications at positions 8, 26 & 34 (Figure 1) that prevent chemical breakdown by DPP-4, and increase binding to albumin
