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Endocrine aspects of opioid use and withdrawal Several drugs (not only opioid) are able to modulate the activity of the hypothalamicpituitaryadrenal (HPA) axis or the sympathetic nervous system, leading to an impaired secretion or activity of respectively cortisol or catechol-amines

As a topical antifungal drug used clinically, clioquinol (5-chloro-7-iodo-8-hydroxyquinoline, CQ) is an analog of 8-hydroxyquinoline

Reconstitution principles remain constant but volumes scale accordingly

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