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However, in another study reporting administration of NR or the CD38 inhibitor GSK987A to mdx mice for 20 weeks 267 , treated mice with the CD38 inhibitor showed increased NAD + levels in muscle tissue, but no improvement was found in muscle function after treatment with either the inhibitor or with NR

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This progression makes sense mechanistically, as cognitive effects from improved neural signaling appear before the structural and neurochemical changes underlying sustained mood improvement have fully developed

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