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Interestingly, a few years ago it has been published that in flies missense mutations of the SLC25A39 homologue shawn results in accumulation of ROS as well as in mitochondrial dysfunction, synaptic defects, and neurodegeneration

(2) the bi-functional catalase-peroxidases, members of a protein family predominantly present among eubacteria and archaea with only two evolutionary branches found in eukaryotic organisms

The use of GSH precursors like N-acetyl cysteine, enhancers of nuclear factor erythroid 2-related factor 2 (Nrf2) like sulforaphane, melatonin, and many more molecules involved in antioxidant defense were proposed as supplementation of other idiopathic pulmonary fibrosis therapies (130)

10.1080/00016489.2016.1183167 Acta Otolaryngol