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J Clin Endocrinol Metab (2013) 98(4):E70812.10.1210/jc.2012-3736 174 UrsellLKMetcalfJLParfreyLWKnightR

Its exceptional structural stability, retained activity in gastric juice for over 24 hours, tolerance across pH 1-11, derives from its high proline content and absence of cleavage-prone motifs in the 15-residue sequence