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However, the large molecular weight, strong hydrophilicity and easy enzymatic hydrolysis of AOD 9604 result in its low bioavailability and limit its clinical application.The rise of nanotechnology has brought revolutionary changes to drug delivery systems

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10.1111/cpr.12268

Theres a newer peptide called PDA, or pentadeca arginate, that has a very similar molecular structure as BPC-157, but instead of it being an acetate, its an arginate essentially just swapping out one amino acid for another

"Cognitive impairment and vitamin B12: a review"