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10.1038/s41586-021-04059-0 Nature 87 GoubernM.AndriamihajaM.NbelT.BlachierF.BouillaudF

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Goal: Studied for telomerase activation, telomere maintenance and circadian/melatonin regulation effects reported mostly in older Russian and preclinical work, not established in humans [5] [6]

But that peripheral-only action means it does not suppress appetite, does not change energy expenditure through central pathways, and does not produce the dramatic caloric deficits that GLP-1 agonists like semaglutide or tirzepatide create