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Therefore, there is a necessity to elaborate on the immunomodulatory effects of the plant using other immune cells, such as monocytes, neutrophils, dendritic cells, and NK cells

Glucagon-Like Peptide-1 and Its Class B G ProteinCoupled Receptors: A Long March to Therapeutic Successes. Pharmacological Reviews, vol

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Xue et al., 2025)

Modulations of gene expression related to inflammatory signaling, angiogenic regulators, cell cycle control, and structural matrix proteins have been documented in preclinical and in vitro systems

Even though this effect may be mediated by the insulin receptor, experimental KO mice for the insulin receptor gene show a potent glucose lowering effect of IGF-1, indicative that the hypoglycaemic effect is also mediated, in part, by its own IGF-1R